US Hwy 441 will take you into Cherokee.įrom Knoxville, TN – approximately two hours.Take I-40 east into North Carolina to Exit 27 (US 74, Great Smoky Mountains Expressway). Our Cherokee maps include road and highway information, as well as the location of many of the area’s best attractions.įrom Asheville, NC – approximately one hour.Take I-40 west to Exit 27 (Great Smoky Mountains Expressway).Continue west on US 74 past Waynesville, Sylva and Dillsboro to Exit 74, Cherokee. There are many winding roads and scenic highways to choose from if you have the time and want to avoid the interstate. Hey, we won’t even judge you for using your handy GPS as long as it gets you here. Making your way through the mountains is no easy task unless you have a good map, and we’ve got one for you.